If you’re flying in, you might consider Albany International Airport, which is only an hour away and is served by American, Delta, JetBlue, Southwest, and United. Most major rental car companies are available there, too, with in-airport service. It’s a well-reviewed small airport, and your experience will be infinitely more pleasant there than if you fly into one of the big New York City airports. From ALB, you’ll take the Thruway south to Catskill/Cairo, and then head about a half-hour west. You can plan Google Maps directions
here.